Are you able to access Profiles view through the vCenter server client (Home -> VM Storage Profiles)?
If you get an error while accessing this view, please try to restart the "VMware vSphere Profile Driven Storage service"
It seems "VMware vSphere Profile Driven Storage service" on the vCenter server is down. So make sure the service is started and running.
Also please check the troubleshooting guide for "Storage Synchronization Job Fails" section.
Is there any firewall setting that might be blocking?
What is output you see when you hit following URL in browser:
These are the possible causes that might cause Storage Sync to fail with the above mentioned stack trace.
Thanks,
Aanjaneya